Calcitriol is a potent active Vitamin D analogue and must be used with extreme caution. Regular monitoring of serum calcium (every 1–2 weeks initially), serum phosphorus, and renal function is mandatory during therapy. Hypercalcaemia is the primary risk of overdose — early symptoms include anorexia, nausea, vomiting, and muscle weakness, progressing to confusion, polyuria, and cardiac arrhythmias if untreated. Concurrent use of thiazide diuretics significantly increases hypercalcaemia risk. Calcium-containing antacids should not be co-administered without medical supervision. Magnesium-containing antacids should be avoided in renal failure patients as it may lead to hypermagnesaemia. This formulation should not be used in patients with hypercalcaemia, metastatic calcification, or Vitamin D toxicity. Not recommended in pregnancy and lactation without specialist guidance. Patients with granulomatous diseases (sarcoidosis, tuberculosis) should use this with caution as they may be hypersensitive to Vitamin D. Store in a cool, dry place below 25°C, away from direct sunlight. Softgel capsules should not be crushed or chewed.
CALCIFED-CT
Calcitriol 0.25mcg + Calcium Citrate 500mg + Zinc Oxide 7.5mg + Magnesium Oxide 50mg SoftGel Capsule
Uses of CALCIFED-CT
Calcitriol 0.25mcg + Calcium Citrate 500mg + Zinc Oxide 7.5mg + Magnesium Oxide 50mg SoftGel Capsule is prescribed for various conditions related to inflammation, pain, and joint disorders.
- Renal Osteodystrophy — Calcitriol directly corrects the calcium-phosphorus imbalance in CKD patients without requiring renal activation, effectively managing renal bone disease.
- Hypoparathyroidism — Provides the active Vitamin D form that bypasses the need for PTH-stimulated renal 1-alpha hydroxylation, correcting hypocalcaemia in hypoparathyroid states.
- Osteoporosis Management — The combination of Calcitriol with Calcium Citrate maximizes bone mineral density restoration, especially in postmenopausal and glucocorticoid-induced osteoporosis.
- Softgel Superior Bioavailability — The lipid-based softgel delivery system enhances dissolution and intestinal absorption of fat-soluble Calcitriol and other micronutrients compared to conventional tablets.
- Comprehensive Bone Nutrition — Zinc supports collagen cross-linking and bone matrix proteins; Magnesium activates alkaline phosphatase and regulates PTH secretion for complete bone metabolic support.
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