Composition : Cefuroxime Axetil 250mg Tablet
Cefixime is an antibiotic that belongs to the class of drugs known as cephalosporins, which are used to treat bacterial infections. The dispersible tablet form of Cefixime is specially designed to be easily dissolved in water for patients who have difficulty swallowing tablets, such as children and elderly individuals. It is effective against a broad range of bacterial infections and is commonly prescribed for conditions such as respiratory tract infections, urinary tract infections, ear infections, and certain types of gastrointestinal infections.
This article delves into the composition, mechanism of action, indications, dosage, side effects, and various other aspects of Cefixime dispersible Tablets.
Composition and Formulation
Cefixime dispersible tablets typically contain the active ingredient Cefixime Dispersible Tablets, which is available in various strengths, including 100 mg, 200 mg, and 400 mg. These tablets are designed to be dispersed in water, making it easier for patients to take the medicine without swallowing whole tablets. The inactive ingredients or excipients used in the formulation may include binders, fillers, disintegrants, sweeteners, and flavoring agents, all chosen to ensure the tablet’s stability, ease of dispersion, and palatability.
Cefixime works by inhibiting the synthesis of the bacterial cell wall. Bacteria are surrounded by a rigid cell wall that provides structure and protection. Cefixime, like other cephalosporins, interferes with the enzymes responsible for building this cell wall. By binding to specific proteins in the bacterial cell membrane, cefixime prevents the bacteria from forming a proper cell wall, leading to the weakening and eventual rupture of the bacterial cell. This bactericidal action helps eliminate the bacteria responsible for causing infections.
Cefixime is effective against both gram-positive and gram-negative bacteria, making it a broad-spectrum antibiotic. Its ability to resist breakdown by certain bacterial enzymes also contributes to its effectiveness in treating a wide variety of infections.
Indications
Cefixime Dispersible Tablets are prescribed for a wide range of bacterial infections. Some of the most common indications include:
Respiratory Tract Infections (RTIs): These include infections such as pneumonia, bronchitis, and sinusitis, caused by susceptible bacteria.
Urinary Tract Infections (UTIs): Cefixime is often used to treat infections in the bladder, kidneys, or urethra caused by bacteria such as Escherichia coli.
Ear Infections: Particularly middle ear infections (otitis media), which are commonly seen in children.
Gastrointestinal Infections: Cefixime can treat bacterial infections such as enteric fever (typhoid fever), caused by Salmonella species.
Gonorrhea: Cefixime is used in the treatment of gonococcal infections, including gonorrhea, caused by the bacteria Neisseria gonorrhoeae.
Soft Tissue Infections: It is sometimes prescribed for infections in the skin and soft tissues caused by susceptible organisms.
It’s important to note that while Cefixime is effective against bacterial infections, it is not effective against viral infections such as the common cold, influenza, or COVID-19.
Dosage and Administration
The dosage of Pharma Franchise for Cefixime dispersible Tablets depends on several factors, including the patient’s age, the type and severity of the infection, and their overall health status. Generally, the recommended dosage is as follows:
Adults and children over 12 years: Adults and children over 12 years:
Children (6 months to 12 years): The dosage is typically based on body weight. It can range from 4 mg to 8 mg per kilogram of body weight per day, administered either as a single dose or divided into two doses.
For severe infections or special conditions he dosage may be adjusted by the prescribing physician.
To ensure optimal absorption, it is recommended that the tablet be dispersed in a small amount of water before consumption. The suspension can be given to children who find it difficult to swallow pills.
Like all medications, PCD Franchise for Cefixime dispersible Tablets can cause side effects. Not everyone will experience these side effects, and some people may experience side effects not listed here. Common side effects include:
Gastrointestinal issues: These are the most frequently observed side effects, including nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it may lead to severe diarrhea due to an overgrowth of Clostridium difficile bacteria in the intestines.
Skin reactions: Rash, itching, or hives may occur. More serious skin reactions are rare but can happen.
Allergic reactions: Some individuals may be allergic to cephalosporin antibiotics. Symptoms of an allergic reaction include swelling of the face, lips, tongue, or throat, difficulty breathing, and severe skin reactions. Immediate medical attention is required for these symptoms.
Liver and kidney effects: Cefixime can sometimes affect liver function, causing elevated liver enzymes. Kidney function may also be impacted, especially in patients with pre-existing kidney issues.
Blood disorders: Rarely, Cefixime may cause blood-related side effects, such as a decrease in the number of red blood cells, white blood cells, or platelets, leading to conditions like anemia or a weakened immune response.
Headache and dizziness: Some individuals may experience mild headaches or dizziness while taking Cefixime.
In most cases, the side effects are mild and subside after the medication is discontinued. However, patients should report any unusual or severe reactions to their healthcare provider.
Precautions and Contraindications
Before taking PCD Franchise for Cefuroxime Axetil Tablets, patients should inform their healthcare provider if they have any of the following:
Allergies: Individuals who are allergic to penicillin, other cephalosporins, or any of the excipients in the formulation should avoid cefuroxime axetil. Kidney disease: The dosage may need to be adjusted for individuals with impaired kidney function. Gastrointestinal disease: Those with a history of gastrointestinal issues, such as colitis, should be cautious when using Cefixime. Pregnancy and breastfeeding: PCD Franchise for Cefuroxime Axetil Tabletss is generally considered safe for use during pregnancy, but it should only be used when necessary. It is excreted in breast milk, so caution is advised when administering it to breastfeeding mothers.
Cefuroxime axetil may interact with certain other medications, including:
Anticoagulants (e.g., warfarin):Cefuroxime may enhance the effects of anticoagulants, increasing the risk of bleeding. Close monitoring is required if both drugs are taken together.
Probenecid: Probenecid can increase the levels of cefuroxime in the blood by reducing its renal clearance. This may require a dose adjustment.
Antacids and H2 blockers: Medications that reduce stomach acid may interfere with the absorption of cefuroxime axetil, making it less effective.
Patients should inform their doctor about all medications they are taking to avoid potential interactions.
Cefuroxime Axetil Tablets are a widely used and effective treatment for a range of bacterial infections. As a second-generation cephalosporin, cefuroxime has a broad spectrum of activity against both gram-positive and gram-negative bacteria. Its convenient oral formulation, especially in the form of a tablet, makes it an accessible option for many patients, including those with respiratory, urinary, skin, and other bacterial infections.
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