Ofloxacin Tablet (OFLORIV-200)
OFLORIV-200 – Advanced Ofloxacin Therapy by Fedley Healthcare
In the fight against bacterial infections, the demand for fast-acting, broad-spectrum antibiotics is higher than ever. Fedley Healthcare proudly introduces OFLORIV-200, a precision-formulated Ofloxacin 200 mg tablet engineered to combat a wide range of bacterial pathogens with unmatched efficacy and safety. As a flagship offering in our antimicrobial portfolio, OFLORIV-200 embodies Fedley's commitment to innovation, quality, and patient-centric care.
Understanding Ofloxacin – A Powerful Fluoroquinolone
Ofloxacin is a synthetic broad-spectrum antibiotic belonging to the fluoroquinolone class. It operates by inhibiting bacterial DNA gyrase and topoisomerase IV—enzymes essential for DNA replication, transcription, and repair. Without these processes, bacterial cells cannot divide and multiply, leading to rapid bacterial death.
Ofloxacin is effective against a diverse range of Gram-positive and Gram-negative bacteria, making it a versatile choice in both community-acquired and hospital-acquired infections. It is particularly effective in treating infections involving the respiratory tract, urinary tract, skin, soft tissues, and gastrointestinal system.
OFLORIV-200: Formulated for Clinical Excellence
OFLORIV-200 by Fedley Healthcare delivers 200 mg of pure Ofloxacin per film-coated tablet. Every tablet is manufactured under stringent quality standards in GMP-certified facilities, ensuring purity, potency, and performance.
Key Features of OFLORIV-200:
- Broad-Spectrum Action: Effective against E. coli, Klebsiella, Pseudomonas, Staphylococcus aureus, Haemophilus influenzae, and more.
- Rapid Absorption: Ensures peak plasma concentration in 1–2 hours for swift therapeutic action.
- Excellent Bioavailability: Over 95%, ensuring most of the active drug reaches systemic circulation.
- Proven Safety Profile: Well-tolerated in most patient groups with minimal adverse effects.
Indications: When to Prescribe OFLORIV-200
OFLORIV-200 is recommended for the treatment of various infections, including:
-
Respiratory Tract Infections
- Acute bronchitis
- Chronic bronchitis exacerbations
- Community-acquired pneumonia
-
Sinusitis
-
Urinary Tract Infections (UTIs)
- Cystitis
- Pyelonephritis
- Urethritis
-
Gastrointestinal Infections
- Infectious diarrhea
- Traveler’s diarrhea caused by Shigella, E. coli, Salmonella
-
Skin and Soft Tissue Infections
- Cellulitis
- Abscesses
- Wound infections
-
Sexually Transmitted Infections
- Uncomplicated gonorrhea
- Chlamydial infections
-
Ophthalmic and ENT Infections
- Otitis media
- Conjunctivitis (systemic treatment adjunct)
Dosage and Administration
Adults:
- The standard dose is 200 mg to 400 mg daily, administered in 1–2 divided doses based on the severity and site of infection.
- Tablets should be swallowed whole with a glass of water, preferably before or after meals.
Duration:
- Treatment typically ranges from 3 to 14 days, depending on clinical response. Always complete the full course, even if symptoms improve early.
Pediatric Use:
- Not generally recommended in children due to potential risks to developing cartilage.
Elderly and Renal-Impaired Patients:
- Dose adjustments may be necessary; clinical monitoring is advised.
Mechanism of Action: Science at Work
OFLORIV-200 operates by binding to DNA gyrase (topoisomerase II) and topoisomerase IV—enzymes responsible for supercoiling and uncoiling bacterial DNA. Inhibiting these enzymes halts replication, eventually leading to cell death. This dual mechanism makes Ofloxacin effective even against resistant strains.
Clinical Advantages of OFLORIV-200
- Superior Pharmacokinetics: With a half-life of 5–7 hours, OFLORIV-200 ensures sustained plasma levels, minimizing dosing frequency and enhancing compliance.
- Low Resistance Development: Compared to older antibiotics, fluoroquinolones like Ofloxacin have a lower incidence of resistance when used appropriately.
- Excellent Tissue Penetration: Ideal for deep-seated infections including bone, lung, and urogenital tissues.
- Convenience and Compliance: Once or twice daily dosing improves adherence, especially in outpatient settings.
Safety Profile and Precautions
OFLORIV-200 has been extensively studied and is generally well-tolerated. However, as with all medications, there are safety considerations:
Common Side Effects:
- Nausea
- Headache
- Dizziness
- Diarrhea
- Insomnia
Rare But Serious Adverse Effects:
- Tendon rupture or inflammation (especially Achilles tendon)
- QT prolongation
- Central nervous system effects (seizures, confusion)
- Photosensitivity reactions
Contraindications:
- Hypersensitivity to fluoroquinolones
- History of tendon disorders related to fluoroquinolone use
- Epilepsy or seizure disorders (use with caution)
Drug Interactions:
- Antacids and calcium supplements can reduce absorption—administer OFLORIV-200 at least 2 hours before or after.
- Warfarin: Increased risk of bleeding—monitor INR.
- NSAIDs: May increase risk of CNS stimulation or seizures.
Storage and Packaging
- Store below 30°C, protected from moisture and direct sunlight.
- Keep out of reach of children.
- Available in aluminum blister packs of 10 tablets, ensuring extended shelf-life and protection.
Why Choose OFLORIV-200 by Fedley Healthcare?
Fedley Healthcare is committed to delivering therapeutics that combine cutting-edge science with deep clinical insight. OFLORIV-200 is not just another antibiotic—it is a result of dedicated research, top-tier manufacturing, and a relentless drive for excellence.
Distinct Advantages with Fedley:
- GMP-WHO Certified Manufacturing
- ISO 9001:2015 Quality Compliance
- Rigorous Batch Testing
- Pan-India Distribution and Availability
- Clinician-Endorsed Formulations
We understand the challenges healthcare providers face in treating bacterial infections effectively while maintaining safety. With OFLORIV-200, Fedley Healthcare empowers physicians to prescribe confidently—knowing that each tablet delivers precision, purity, and proven results.
Empowering Healthcare, One Dose at a Time
At Fedley Healthcare, we view pharmaceuticals not just as products, but as lifelines. OFLORIV-200 is a testament to our promise: to provide dependable, affordable, and innovative treatments to all. As bacterial resistance evolves, our commitment to antimicrobial excellence remains unwavering.
Join the Fedley Movement
Partner with Fedley Healthcare in our mission to provide quality-driven, patient-focused therapy. With OFLORIV-200, clinicians are not only treating infections—they are restoring health, safeguarding futures, and redefining recovery.
