`Ofloxacin Nitazoxanide Tablet (OFLORIV-NZ)

OFLORIV-NZ

Ofloxacin 200 mg + Nitazoxanide 500 mg Tablet
Advanced Dual-Action Antimicrobial Therapy by Fedley Healthcare

In the modern age of antimicrobial resistance and complex infections, mono-therapy often falls short. To meet the evolving challenges of gastrointestinal and mixed microbial infections, Fedley Healthcare introduces OFLORIV-NZ, a dynamic dual-action tablet combining Ofloxacin 200 mg and Nitazoxanide 500 mg. This scientifically optimized combination delivers a synergistic punch against both bacterial and protozoal infections, ensuring quick relief and complete recovery.

As a trusted name in pharmaceuticals, Fedley Healthcare is proud to expand its antimicrobial portfolio with this power-packed combination, reflecting our ethos—Precision in Formulation, Compassion in Healing.

Product Composition

• Ofloxacin 200 mg – Broad-spectrum antibacterial
   

• Nitazoxanide 500 mg – Potent antiprotozoal and antiviral agent
   

Each film-coated tablet of OFLORIV-NZ is formulated to provide superior bioavailability, excellent tolerability, and effective multi-pathogen control.

Understanding the Components

Ofloxacin

A 2nd-generation fluoroquinolone, Ofloxacin inhibits DNA gyrase and topoisomerase IV, key enzymes involved in bacterial DNA replication. It is highly effective against Gram-positive and Gram-negative bacteria and remains a go-to choice in various systemic infections.

Nitazoxanide

Nitazoxanide, a thiazolide class drug, works through interference with the pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, essential for anaerobic energy metabolism. It acts on protozoa (e.g., Giardia, Entamoeba), helminths, and even viral infections like rotavirus and norovirus.

Why OFLORIV-NZ? The Dual Advantage

1. Comprehensive Spectrum – Targets bacteria + protozoa + anaerobes.
    
2. Faster Symptom Relief – Combined action clears infection faster and minimizes recurrence.
    
3. Reduced Resistance Risk – Combination therapy reduces the emergence of resistant strains.
    
4. Enhanced Compliance – Single-tablet therapy minimizes pill burden.
    

Indications – When to Prescribe OFLORIV-NZ

OFLORIV-NZ is ideal for gastrointestinal and systemic infections involving mixed pathogens. Key indications include:

1. Acute Diarrheal Diseases

• Infectious diarrhea of mixed etiology
   
• Traveler’s diarrhea
   
• Dysentery (amoebic or bacillary)
   

2. Protozoal Infections

• Giardiasis
   
• Amoebiasis (intestinal and hepatic)
   

3. Typhoid and Paratyphoid Fever

• Especially in cases involving drug-resistant strains
   

4. Gastroenteritis with Parasitic Load

• In areas of poor sanitation or high protozoal burden
   

5. Mixed Infections

• Infections involving E. coli, Shigella, Salmonella, Entamoeba histolytica, and Giardia lamblia
   

Dosage & Administration

• Adults: One tablet twice daily (every 12 hours) for 3–5 days or as prescribed by the physician.
   
• Pediatric Use: Not recommended in children under 12 years.
   
• Elderly: Use with caution; renal function should be assessed.
   
• Tablets should be taken with water, preferably after meals.
   

Safety Profile

OFLORIV-NZ is generally well tolerated. Mild side effects may include:

• Nausea or vomiting
   
• Abdominal discomfort
   
• Headache
   
• Dizziness
   
• Transient changes in liver enzymes
   

Contraindications:

• Hypersensitivity to fluoroquinolones or nitazoxanide
   
• Severe renal or hepatic impairment
   
• Pregnancy and lactation (use only if clearly needed)
   

Drug Interactions:

• Avoid concurrent use with antacids or mineral supplements (interferes with Ofloxacin absorption).
   
• Monitor if used alongside warfarin or antidiabetic agents.
   

Scientific Backing

• Clinical studies have shown combination therapy (Ofloxacin + Nitazoxanide) results in a higher cure rate and faster recovery in infectious diarrhea than monotherapy.
   
• The combination provides a broad umbrella coverage, reducing the need for second-line or IV antibiotics.
   

Storage & Packaging

• Store below 30°C, away from direct sunlight and moisture.
   
• Packed in 10 x 10 aluminum blister strips, sealed for freshness and durability.
   

A Product by Fedley Healthcare: Where Quality Meets Purpose

At Fedley Healthcare, each product is a promise—crafted with GMP-WHO certified manufacturing and a rigorous QA/QC pipeline to ensure every dose is consistent, safe, and effective.

With OFLORIV-NZ, we are addressing a critical therapeutic gap in developing and tropical regions where mixed gastrointestinal infections are common, yet poorly managed.

Franchise Opportunity – Grow with Fedley Healthcare

We’re not just offering OFLORIV-NZ—we’re offering an opportunity. Join one of India’s fastest-growing ethical pharma brands and launch your own pharma business with Fedley Healthcare’s PCD Pharma Franchise Model.

Why Choose a Fedley Franchise?

 High-Profit Margins
Monopoly Rights (Territory-Wise)
Attractive Promotional Inputs – MR bags, visual aids, samples, brochures
Timely Dispatch & Transparent Pricing
Wide Product Portfolio – Covering antibiotics, antivirals, nutraceuticals, pain management, and more
Dedicated Franchise Support Team

Ideal For:

• Medical Representatives aiming to start their business
   
• Distributors seeking monopoly in their region
   
• Healthcare entrepreneurs looking for branded generics
   

Partner With Us – Let’s Build Healthcare Together

Fedley Healthcare invites motivated partners from all across India to become part of our growing franchise network. We believe in mutual growth and shared vision—where your success is our achievement.

Whether you're entering the pharmaceutical business for the first time or expanding your current portfolio, OFLORIV-NZ and our diverse range of formulations are ideal starting points.

Conclusion: OFLORIV-NZ—A Smart Choice for Smarter Healing

OFLORIV-NZ by Fedley Healthcare is not just a tablet—it’s next-gen gastrointestinal therapy. With the dual action of Ofloxacin and Nitazoxanide, we bring a scientifically validated, patient-friendly, and cost-effective solution to frontline healthcare professionals.

Fedley Healthcare is proud to provide this potent combination to clinics, hospitals, pharmacies, and healthcare providers across India.